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What is avanafil?

Avana is an oral drug used in male patients with confirmed diagnosis of erectile deficit. The drug is taken on demand, prior to sexual activity, with its action providing symptomatic recovery for the period of time that lasts between 4 and 5 hours.

Avana has avanafil citrate as its basic active component. Avanafil, which has been on the market for a few years (having been approved for the treatment of erectile dysfunction in 2012), is very fast in the action that occurs within 15-30 minutes of taking it and has a duration of 4-5 hours and perhaps fewer side effects.

Mechanism of action


The active ingredient of Avana, avanafil, is as effective as other drugs in its family of PDE5 inhibitors, but it is better tolerated even at higher dosages. This is demonstrated by a study conducted by Italian researchers on about 2 thousand patients.

The analysis, conducted on the data of about 2 thousand patients enrolled in five different randomized and controlled clinical trials, shows that thanks to the peculiar pharmacological profile this molecule has a greater tolerability than the well-known first generation drugs of the same class. This characteristic can help to avoid the widespread abandonment of therapy among men with erectile dysfunction: up to 60-70% of patients stop taking the drugs within a year of the first prescription.

Avanafil, the active ingredient of the pill can help men with erectile dysfunction to live sexuality without worries because those who hire them need not worry about it hurting, working or starting to work too late. In comparison with sildenafil, vardenafil and tadalafil, active ingredients with which it shares the mechanism of action, but which are part of the first generation of phosphodiesterase-5 inhibitors, it has the same efficacy but guarantees a lower load of side effects such as headache, congestion nasal, flushing, visual disturbances, back pain: moreover, even at the highest dose of 200mg, which has proven to be extremely effective, there is no risk of increased adverse events. This tolerability – he added – is very useful because we know that the prescription of a drug against erectile dysfunction is repeated after the first 3-4 months only by 62% of patients, after a year the percentage of abandonment of therapy goes up to 60-70%. These data suggest that men stop taking drugs for reasons other than a lack of efficacy: many stop because they do not tolerate illness, but adherence to treatment is essential for the treatment to work.

How much avanafil should I take?

Avanafil is the safest of the hitherto developed oral drugs for the treatment of ED; it can therefore be used in the elevated doses of up to 200 mg, speeding up the onset and providing more significant results faster and in a more intense manner.

This said, it is always of paramount importance to have your dosage and posology approved by certified member of medical board before you start taking Avana. It is up to your prescriber to determine the maximal allowed dose of avanafil for you individually.

Is avanafil safe?

Avanafil is reportedly as effective against erectile dysfunction as first-generation drugs, but with fewer side effects. Avanafil, the active ingredient of so-called “love pills” is in fact better tolerated, even at higher dosages. Therefore, not presenting any risk of an increase in adverse events, it is therefore possible to continue the therapy without abandoning it, as in the case of up to 60-70% of cases.

All this, along with excellent efficacy, with a satisfactory effect in 80% of cases and also in the presence of severe erectile dysfunction, considering the safety profile of avanafil, makes it is reasonable to prescribe it at the highest dosage of 200 milligrams, especially in the most complex cases, to get a response faster.

What is better avanafil, vardenafil or Viagra?

The differences between avanafil, vardenafil and sildenafil (Viagra) are minimal, apart from the tadalafil which stands out as regards the duration of action; there are a number of phase 3 drugs in preparation with the sole aim of improving and personalizing the therapy. It is always mandatory to rely on a reference andrologist to verify the need and the right dosage of the erection drug therapy which, as we have seen, it can have certain benefits, but also side effects that should be known and avoided when possible.

Finally, one of the characteristics that make avanafil stand out is its mode of action: it acts very quickly, freeing the need to plan the relationship and making it more spontaneous. Let us not forget that the goal of erectile dysfunction therapy is the return to a natural and satisfying sex life: the characteristics of avanafil make it fit for purpose, given that 4 men out of 10 consider a drug that works within 20 minutes ideal.

Side effects

Although rare, Avana side effects can manifest themselves as the following:

  • Hot flashes
  • Electrocardiographic alterations
  • Hypertensiona
  • Nausea
  • Dyspepsia
  • Diarrhea
  • Constipation
  • Headache
  • Vertigo
  • Back pain
  • Arthralgia
  • Nasopharyngitis
  • Nasal congestion
  • Sinusitis
  • Upper airway infections
  • Bronchitis


The lower probability of side effects depends on particular characteristics that make avanafil more selective than the “classic” medicines against erectile dysfunction; this feature also reduces the likelihood of interactions with other drugs (however, the absolute prohibition of taking it with nitrates that are used for angina pectoris remains) and eliminates the need to adjust dosages in the case of elderly patients, with diabetes or with insufficiency mild or moderate kidney disease, making the pill much easier to manage.



The use of Avana is contraindicated in patients with:

  • kidney / liver impairment
  • heart failure / heart disease / stroke
  • inadvisability of sexual or any other physical activity
  • congenital eye problem called retinitis pigmentosa
  • eye nerve condition called NAION
  • a number of blood cell diseases
  • ulcerative diseases of GTI
  • sensitivity towards avanafil

Before proceeding to take Avana, inform your prescriber about current and past health conditions so that they make a fully informed decision as for risks to benefits ratio of avanafil therapy in your specific case.

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Customer reviews
By Raul
Posted on 22/11/2019
In an alldaychemist review of Avana, I was reading that avanafil is superior to any other existing impotence pill. How much truth is there in this statement? Thanks.
By James Daniels M.D.
Posted on 24/11/2019
According to numerous researches on avanafil, the substance is faster-acting and safer than other drugs in its class (oral inhibitors of PDE5). The drug features very low side event profile, which allows taking it in elevated doses, and larger doses are linked to better results in some individuals. There is no one-size-fits-all kind of answer though: you will still need to try taking Avana to establish the response of your body to it. Remember to check with your doctor if you are eligible for the therapy with avanafil.