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Manufacturer: GlaxoSmithKline Pharmaceuticls Ltd.
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What is Zyban?


Zyban (bupropion) is an oral medication that reduces the severity of anxiety states. Its use is justified when anxiety becomes unbearable and lasts over time. Unlike other anxiolytic drugs it does not promote sleep.

Bupropion (also known as amfebutanone) is an atypical antidepressant whose structure closely resembles that of amphetamine, a powerful stimulant of the central nervous system. However – despite the similarity with amphetamine – bupropion has a completely different pharmacological activity.

Zyban is available for oral administration as tablets. As the drug can cause sleep disturbances, taking the tablets before bedtime is not recommended.

Zyban is a drug that is not only used for the treatment of major depression, but is also used in smoking cessation therapy. In fact, in addition to inhibiting dopamine reuptake (a mechanism responsible for the antidepressant action), the drug also has an antagonistic action against nicotinic receptors already at therapeutic concentrations.

Mechanism of action

Zyban – thanks to its mechanism of action – is able to reduce nicotine cravings in patients, also reducing the discomfort and symptoms induced by abstinence. Furthermore, the drug is able to reduce the risk of relapse.

Uses and dosage

Zyban dosage must be established by the doctor on an individual basis. In any case, the dose of drug normally used is 150 mg of active ingredient, to be taken once a day. The dose can be increased up to 300 mg. In patients with hepatic and / or renal insufficiency a reduction in the dose of bupropion administered may be necessary. Although no cases of withdrawal symptoms have been reported, abrupt termination of therapy is not recommended; instead, a gradual reduction of the dose is recommended.

Zyban directions

Zyban should be taken by mouth, at the doses indicated by the doctor. Do not increase the number of tablets taken every day and do not extend the treatment beyond the prescribed period. It usually takes 1-2 weeks for the drug to fully develop its effectiveness, so treatment should not be interrupted too soon if no improvement is observed.

Store the drug at room temperature, in a cool, dry place away from light. Do not use the drug if the label indicates that it has expired. Keep it away from children. Store the medicine in the original package together with the package insert.

Zyban vs Wellbutrin – which is better?


Wellbutrin is a medicine prescribed by your doctor to treat your depression. It is thought to interact with chemicals in the brain called noradrenaline and dopamine, which are linked to depression. The active ingredient is bupropion hydrochloride. Each tablet contains 150 mg or 300 mg of bupropion hydrochloride.

It is up to your prescriber to determine which of the two medications is best for you, proceeding from a) response to therapy and b) susceptibility towards side effects of either of the drugs.

Zyban vs Zoloft – what to choose?

Zoloft (sertraline) is an antidepressant drug belonging to the selective serotonin reuptake inhibitor class. Furthermore, sertraline also has a weak action on the re-uptake of noradrenaline and dopamine. The use of sertraline is indicated for the treatment of:

  • Depression;
  • Social anxiety disorder;
  • Panic attacks, phobias;
  • PTSD;
  • OCD.

The use of bupropion is limited to the treatment of major depressive disorder, so its application is limited to this specific subpopulation. However, Zyban is also appointed in patients fighting nicotine addictions.

What is the difference between Zyban and Champix?

Champix (varenicline) is a drug with specific indications to help patients stop smoking. Champix represents an alternative to the use of other drugs used to combat smoking addiction, such as Zyban and nicotinic replacement therapy.

Some studies have shown that Champix may be more effective than Zyban in smoking cessation therapy and relapse prevention. However, you should rely on prescriber’s opinion when choosing your quit-smoking drug.

Zyban vs Chantix

Chantix (varenicline) is a full analog of Champix, the drug described in the paragraph above. When compared to Zyban and its application, they are used interchangeably, with Chantix effects for smoking cessation being more promising but less studied. However, while Zyban is also used in depression disorder treatment, Chantix is strictly a nicotine dependence drug whose use is limited to helping in quitting smoking.

Side effects

In addition to the expected health effects, Zyban can cause the onset of certain side effects. This drug is generally well tolerated; however, sometimes disorders such as: dizziness, nausea, diarrhea, stomach pain, headache, agitation, insomnia or drowsiness and tingling in the limbs may occur. Tell your doctor if you have any other problems while taking the medicine. Tell your doctor if you have any other complaints due to taking the medicine.



Some side effects can be enhanced by alcoholic beverages which should therefore be avoided.

If you are taking other anxiolytics containing substances called “benzodiazepines” you should not immediately stop using it (unless otherwise advised by your doctor), since this drug is not effective before ten days.

Report the medications you are taking; if you have serious kidney or liver or other organ diseases; if you have suffered in the past from “allergies” to drugs or diseases such as eczema, asthma, hives.

Report if a work activity is taking place that involves particular dangers and requires a particularly intense state of attention.

(For patients): Report if you are pregnant or breast-feeding or if a pregnancy is possible.


You should not take other drugs with sedative effects concomitantly with Zyban, for instance medications for allergies (antihistamines), products to treat cold symptoms, pills for insomnia and other drugs that the doctor or pharmacist will be able to indicate.

Posted in Quit Smoking

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Customer reviews
By Linda
Posted on 28/11/2019
I’m a 35-year-old girl with about 20 kg to lose, with no particular health problems. I went to a dietician who prescribed me a moderately restrictive diet and tablets of Zyban. I’ve already lost 8 kg in almost 4 months and I don’t feel any particular effects of the pills on my health. I would like to understand what these substances are, if they have side effects and how long they can be taken.
Furthermore, in this diet, in addition to the usual forbidden things (sweets, fried foods, etc.), dairy products are not allowed (only a glass of milk a day) and legumes are prohibited. Is it something that can create imbalances over time? I thank in advance anyone who wants to clarify my doubts. Sincerely, Linda
By James Daniels M.D.
Posted on 30/11/2019
Dear Linda, Bupropion contained in Zyban is a molecule available as an antidepressant, I is used to facilitate detachment from tobacco smoke. 300 mg is an average dose in general. The central problem is that the psychiatric diagnosis has been excluded, and any risk factors for psychic reactions collected. Furthermore, the use of Zyban can facilitate a restrictive diet but does not change a fundamental fact, namely the fact that restrictive diets do not offer a guarantee of maintaining the weight achieved. The intake of these products in the dietary field is usually conceived as a supplementary aid.